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KMID : 1134820200490060539
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Journal of the Korean Society of Food Science and Nutrition
2020 Volume.49 No. 6 p.539 ~ p.546
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Effect of Korean Red Ginseng Extract (KGC05P0) on Regulating Insulin Sensitivity, Insulin and Blood Glucose Level in Hyperinsulinemia Type 2 Diabetic Mice
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Kwon Han-Ol
Koo Gi-Bang
Lee Yun-Ji
Kim Jong-Han
Lee Mi-Hyang
In Gyo
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Abstract
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Orean red ginseng extracts (KGC05P0) showed anti-diabetic activity, especially regarding fasting blood glucose and insulin sensitivity in vivo, in this study. To confirm their effectiveness in animals, C57BL/6J ob/ob (hyperinsulinemia/diabetic model) mice were orally administrated with or without KGC05P0 for 12 weeks. The experimental group was divided as follows: NC (C57BL/6J mice), C (C57BL/6J ob/ob mice), Met 200 (metformin, 200 mg/kg b.w.), P0 100(KGC05P0, 100 mg/kg b.w.), P0 200(KGC05P0, 200 mg/kg b.w.), and P0 400(KGC05P0, 400 mg/kg b.w.). We found that KGC05P0 significantly reduced fasting glucose and insulin levels in serum and increased the serum adiponectin level. KGC05P0 improved insulin sensitivity modulators such as IR, IRS-1, PI3K, Akt, AMPK, and GLUT2/4 and inhibited liver function indicators in the liver. This suggests that KGC05P0 has great potential as a health food for improving blood glucose.
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KEYWORD
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Korean red ginseng, non-saponin fraction , insulin sensitivity, fasting blood glucose, hyperinsulinemia
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